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In addition, the median time to onset of any-grade hepatic events (29.0 d), diarrhea/colitis (18.0 d), dermatitis/rash (24.0 d), and endocrine events (57.0 d) for participants who received STRIDE in our study differed when compared with the phase I/II multicohort CheckMate040 study (NCT01658878), which assessed multiple doses of nivolumab plus ipilimumab and reported an approximate median time to onset of hepatitis (39.256.7 d), diarrhea/colitis (58.8172.2 d), rash events (14.7135.8 d), and endocrine events (hyperthyroid events, hypophysitis, and hypothyroid events
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According to 2022 research published in Frontiers in Endocrinology (Lausanne), TB-4 may offer anti-inflammatory effects that may be used for various issues, including myocardial infarction and myocardial ischemia-reperfusion injury, xerophthalmia, liver and renal fibrosis, ulcerative colitis and colon cancer, and skin trauma ( 13 )
Urine was collected from the female subjects for urine pregnancy testing
